排序 | 配体 | 溶剂 | 反应时间(h) | 反应温度(℃) | 配体/苯乙酮(mol%) | 产率a(%) | eeb(%) | 产物构型b |
1 | (R)-1 | THF | 120 | −10 | 5.0 | 88 | 37 | R |
2 | (R)-1 | THF | 90 | −5 | 5.0 | 98 | 36 | R |
3 | (R)-1 | THF | 72 | 0 | 5.0 | 92 | 27 | R |
4 | (R)-1 | THF | 60 | 室温 | 5.0 | 98 | 19 | R |
5 | (R)-1 | CHCl3 | 90 | −5 | 5.0 | 81 | 30 | R |
6 | (R)-1 | CH3OH | 90 | −5 | 5.0 | 85 | 28 | R |
7 | (R)-1 | THF | 90 | −5 | 6.0 | 99 | 37 | R |
8 | (R)-1 | THF | 90 | −5 | 4.0 | 87 | 32 | R |
9 | (S)-1 | THF | 90 | −5 | 5.0 | 97 | 35 | S |